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conferenceseries.com
Volume 2, Issue 4 (Suppl) Breast Can Curr Res, an open access journal Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4th World Congress on
Breast Pathology and Cancer Diagnosis
Rani Kanthan, Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-008
Adenoid cystic carcinoma of the breast- A focused review
Rani Kanthan
University of Saskatchewan, Canada
Adenoid cystic carcinoma [ACC] is the most common malignant epithelial tumor of the minor salivary glands and is
characterized by the presence of a dual population of both epithelial/luminal and myoepithelial/basaloid (abluminal) cell
proliferation. Rarely, ACC is detected outside of the salivary glands in locations including the uterine cervix, bartholin’s glands,
lacrimal glands, auditory canal, skin, upper respiratory tract and lung, kidney, esophagus, prostate, and breast. Adenoid cystic
carcinoma of the breast is rare, with an incidence of ~1/1 million female-years, a rate that has remained stable since the 1980s
despite increases in mammogram screening. These tumors usually occur in Caucasian women, though rarely this tumor has
also been reported in the male breast. This talk will provide a focused review on the clinical features, radiological findings,
and key pathological features including the unique immunohistochemical staining properties with a brief purview on the
differential diagnosis. The controversial views on its histopathogenesis will be explored including the underlying molecular
mechanisms. Similarities and differences to salivary gland tumors will be highlighted. Best practice management and the role
for surgery, radiotherapy, chemotherapy and hormonal therapy will be discussed. This talk will conclude with an update on the
prognostic and predictive factors of this unique breast tumor.
Biography
Rani Kanthan is a Consultant Anatomical Pathologist in the Dept. of Pathology and Laboratory Medicine at the University of Saskatchewan with a focused interest
in surgical oncology including breast and gastrointestinal tract. She has published more than 100 peer reviewed manuscripts that are indexed in PubMed/Google
scholar and serves as an Editorial Board Member in various journals. She is an active educator and continues to participate and present at various national and
international meetings.