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conferenceseries .com
6th World Congress on
October 16-18, 2017 | San Francisco, USA
Breast Cancer & Therapy
Volume 2, Issue 5 (Suppl) Breast Can Curr Res, an open access journal Breast Cancer Congress 2017
October 16-18, 2017
Chemotherapy with anti-cancer drugs specific to acidic nests
Hiroshi Kobayashi
Chiba University, Japan
It was found more than 80 years ago that solid cancer nests are acidified, but in vitro studies under acidic conditions had not been
focused for a long time. We started in vitro experiments with mammalian cells under acidic conditions in 1996. After the protocol
for culturing cancer cells in acidic medium had been establised, the anti-cancer efficacy of four drugs; lovastatin, cantharidin,
manumycin A and ionomycin, were found to increase dramatically at acidic pH. In the case of statins, no serious side effects, such as
dysfunction of immune system, pain, diarrhea, nausea, and hair loss, have been reported. These results suggest that these drugs are
specific to acidic nests with less effects on normal tissues. In addition to these drugs, many other anti-cancer drugs, specific to acidic
nests could be exploited in future, because approximately 700 genes were found to express at a higher level under acidic conditions
and such genes may be potent targets for anti-cancer drugs specific to acidic nests. On the basis of our data obtained from in vitro
studies, clinical usages of anti-cancer drugs specific to acidic nests are discussed.
Biography
Hiroshi Kobayashi received his PhD in Biochemistry from the University of Tokyo in 1974. After his Post-doctoral training at Colorado University Medical Center, he started
to study adaptation strategies of microorganisms to acidic environments at Chiba University in 1978. His research was focused on mammalian cell functions under acidic
conditions from 1996 at Graduate School of Pharmaceutical Sciences, Chiba University. He retired in March 2012 and is a presently Professor Emeritus at Chiba University
after his retirement. He works as an Associate Editor of International Immunopharmacology published by Elsevier BV from 2014.
Hiroshi Kobayashi, Breast Can Curr Res 2017, 2:5 (Suppl)
DOI: 10.4172/2572-4118-C1-011