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conferenceseries
.com
6
th
World Congress on
October 16-18, 2017 | San Francisco, USA
Breast Cancer & Therapy
Volume 2, Issue 5 (Suppl)
Breast Can Curr Res, an open access journal
Breast Cancer Congress 2017
October 16-18, 2017
Bioinformatic analysis of aberrant glycosylation in Triple negative breast cancer
Navkiran kaur, Apoorva Mathur, Abhishree Aggarwal, Sakshi Gupta
and
Tuhin Rashmi
Amity Institute of Biotechnology, India
B
reast cancer is the most common cancer in women worldwide, and resistance to the current therapeutics, often concurrently, is an
increasing clinical challenge. Glycosylation of proteins is one of the most important post translational modifications. It is widely
known that aberrant glycosylation has been implicated in many different diseases due to changes associated with biological function
and protein folding. Alterations in cell surface glycosylation, can promote invasive behavior of tumor cells that ultimately lead to the
progression of cancer. In breast cancer, there is increasing evidence pertaining to the role of glycosylation in tumor formation and
metastasis. In the present study an attempt has been made to study the disease associated sialoglycoproteins in breast cancer by using
bioinformatics tools. The sequence will be retrieved from uniprot database. A database in the form of a word document was made by
collection of FASTA sequences of breast cancer gene sequence. Glycosylation was studied using yinOyang tool on expasy ,followed
by involvement of differentially expressed genes in important molecular and signaling casades using KEGG, DAVID and Ingenuity
databases.The number of residues predicted O-glc NAc threshold -2 or more was detected and recorded for individual sequence. We
found that the there is a significant change in the expression profiling of glycosylation patterns of various proteins associated with
Triple negative breast cancer. Differential aberrant glycosylated proteins in breast cancer cells with respect to non-neoplastic cells are
an important factor for the overall progression and development of cancer.
Biography
Navkiran Kaur has completed her PhD in 2007 from Postgraduate Institute of Medical Education and Research, Chandigarh and worked as Senior Research fellow in the
same institute. Presently, she is working as Assistant Professor in Amity Institute of Biotechnology, Amity University, and NOIDA. She is working in the area of protein gly-
cosylation and breast cancer and has published papers in reputed journals. She has been sanctioned with a government funded project from UP CST in the field of Breast
cancer as Co-investigator
navkirank@amity.eduNavkiran kaur et al., Breast Can Curr Res 2017, 2:5 (Suppl)
DOI: 10.4172/2572-4118-C1-011