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conferenceseries
.com
6
th
World Congress on
October 16-18, 2017 | San Francisco, USA
Breast Cancer & Therapy
Volume 2, Issue 5 (Suppl)
Breast Can Curr Res, an open access journal
Breast Cancer Congress 2017
October 16-18, 2017
The role of the corepressor N-CoR1 related to TNF-alpha-mediated apoptosis in Breast cancer cells
Seung-Ho Park, Sungmin Kwak, Gi-Jun Sung, Ji-Hoon Jeong, Ji-Hye Song, Hee-Bum Kang
and
Kyung-Chul Choi
University of Ulsan College of Medicine, Korea
W
e have investigated the role of corepressor N-CoR1 in ERα(+) breat cancer cells. The nuclear receptor corepressor NCoR1 plays
an important role in the TNF-alpha-mediated apoptosis. but little is known about what regulates ER alpha-NCoR complex in
breast cancer cells. Therefore, we have found that TNF-alpha markedly down-regulates NCoR1 protein levels in ERα(+) MCF7 breast
cancer cells. Also, the reduced NCoR1 expression by TNF-α was induced the down-regulation of ERα protein levels in the MCF7
cells. This result suggests that NCoR1 expression may be involved in the TNF-α-mediated apoptosis of ERα(+) breast cancer cells.
Interestingly, the phosphorylation of NCoR1 by CK2 inhibited the ubiquitin-dependent proteasomal degradation of NCoR1 in the
TNF-a-treated MCF7 breast cancer cells. Eventually, the down-regulation of NCoR1 and ER by TNF-α was increased the activation of
p53. Thus, our results show a mechanism by which the TNF-α treatment induces the dissociation of ERa-NCoR-p53 complexes and
activiates the p53-dependent pro-apoptosis target genes through the acetylation of p53. These findings reveal that ERɑ -p53-NCoR1
complexes represses the transcription activity of apoptosis genes, such as p21, Bax and Puma.
Biography
Seung-Ho Park has studied his MS course from University of Ulsan Colleage of Medicine. His major is Medical Science. He heartily has been studying at Therapy of breast
cancer. He recently published paper in Journal of Medicinal Food.
shpark9322@gmail.comSeung-Ho Park et al., Breast Can Curr Res 2017, 2:5 (Suppl)
DOI: 10.4172/2572-4118-C1-012