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Biopolymers and Bioplastics 2016
September 12-14, 2016
Volume 7, Issue 5(Suppl) J Bioremed Biodeg 2016
ISSN: 2155-6199 JBRBD, an open access journal
conferenceseries .com
September 12-14, 2016 San Antonio, USA
3rd International Conference and Exhibition onBiopolymers & Bioplastics
Dula Man et al., J Bioremed Biodeg 2016, 7:5(Suppl)
Multilayer core-sheath nanofiber scaffolds used in the differential release of bioactive molecules
Dula Man, B Sansbury and R Wu
Delaware State University, USA
The core-sheath nanofiber and hydrogel exhibit great potential in drug delivery field. It is desirable to differentially control
the release rate of different drugs from the same drug delivery vehicle. Biocompatible and biodegradable materials,
polycaprolactone (PCL) nanofibers and alginate hydrogels, play a significant role in both designing controlled release
matrix for cell culture and tissue growth. Although prolonged release of bioactive molecules is readily achievable using these
polymer materials independently as a matrix, it is not seen how to release various bioactive molecules at a different rate over a
different length of time. In this study, we fabricated a multilayer PCL-PEO core-sheath nanofiber scaffold in combination with
sandwiched layers of either alginate hydrogel or uniaxial electrospun PCL-gelatin nanofiber layers, and evaluated its controlled
release property. Adenosine triphosphate (ATP) or glucose was encapsulated in the PEO core of the core-sheath nanofibers,
and the release kinetics was studied. We demonstrated that ATP release from the exposed top layer of the scaffold has higher
burst release and shorter release time compared to that from deeper layers in the scaffolds. Such a differential release property
of designated layers can be employed to achieve releasing of multiple drugs at different rates over a different length of time.
Biography
Dula Man is an Assistant Professor at Delaware State University. He has completed his PhD in Molecular Biology from the University of Texas at El Paso, and
Post-doctorate at University of California Irvine. He has navigated the science fields from molecular biology, biochemistry, structural biology, DNA repair, genome
edting to nanomaterial engineering. He has published numerous refereed papers.