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conferenceseries.com
Volume 7, Issue 2 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biomaterials 2017
March 27-28, 2017
2nd Annual Conference and Expo on
March 27-28, 2017 Madrid, Spain
J Biotechnol Biomater 2017, 7:2 (Suppl)
Polymer electrode material for microbial bioelectrochemical systems
A Chtaini
Université Sultan Moulay Slimane, Morocco
Bioelectrochemical systems based on polymer-bacteria thin film modified electrode were explored. The prepared polymer-
bacteria modified copper electrode was characterized with voltametric methods, as cyclic voltammetry (CV) and electrochemical
impedance spectroscopy (EIS). The proposed electrode indicated a definite redox response, high conductivity and electrochemical
stability. The experimental results revealed that the prepared electrode could be a feasible for degradation of hazardous phenol
pollutants. Oxidation of phenol was invested by cyclic voltammetry and EIS. EIS diagrams resulted in separate time constants; the
oxidation of phenol is mostly represented by half a circle, whose diameter corresponds to the electron transfer resistance. Electron
transfer resistance produced by polymer-bacteria modified copper electrode is less than that obtained by polymer modified copper
electrode.
Synthesis and solubilization of flurbiprofen derivatives and investigation of their biological activities
Muhammad Mustaqeem, Musa Kaleem Baloch, Irfan Ullah, Ammarah Luqman and Fouzia Batool
University of Sargodha, Pakistan
Flurbiprofen is one of the most potent non-steroidal anti-inflammatory drugs. It is widely used for relief of pain in patients suffering
from rheumatic diseases, migraine, sore throat and primary dysmenorrhea. However, its aqueous solubility is very low and hinders
the skin permeation. Thus, it is imperative to develop such a drug delivery systems which can improve its aqueous solubility and
hence improve the skin permeation and therapeutic compliance. Micro-emulsions have been also proven to increase the cutaneous
absorption of lipophilic drugs as compared to conventional vehicles. Micro-emulsion is thermodynamically stable emulsion that has
the capacity to ‘hide/solubilize’ water-insoluble molecules within a continuous oil phase. Therefore, flurbiprofen was converted to
esters through chemical reactions with alcohols such as methanol, ethanol, propanol and butanol. The product was further treated
with hydrazine to get hydrazide. The solubility of the parent drug flurbiprofen and the products were solubilized in micro-emulsions
formed using various surfactants like ionic, non-ionic and zwitterions. It has been concluded that the product was more soluble than
the parent compound. The biological activities of these were also investigated. The outcome was very promising and the product was
more active than the parent compound. It therefore concluded that in this way we can not only enhance the solubility of the drug,
increase its bioactivity but it also reduces the risk of stomach cancer.