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Volume 7, Issue 2 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biomaterials 2017
March 27-28, 2017
2nd Annual Conference and Expo on
March 27-28, 2017 Madrid, Spain
Marco Consumi et al., J Biotechnol Biomater 2017, 7:2 (Suppl)
Novel extended-released polymeric matrix for Monascus fermented rice extract (RYR) delivery
Marco Consumi, Leone G, Pepi S and Magnani A
University of Siena, Italy
Monascus fermented red rice (RYR) has been demonstrated to lower cholesterol in blood and sold over-the-counter as an
alternative to cholesterol-lowering statin drugs, especially for who stopped statin drugs due to their side effects. The goal
of this work is to develop an extended-release formulation, able to maintain the activity effect against the cholesterol, obtaining a
constant release of statins present in RYR throughout the staying of the tablets inside the intestine. This study focus on the analysis
of different carriers for controlled release systems composed by polysaccharide-based matrices by two different formulations based
on K-Carrageenan and Gellan gum (ranging from 10-90% in weight). Samples as cylindrical tablets have been physicochemical
characterized by FTIR, DSC, TGA, Rheometer and TOF-SIMS, water uptake, water bond, water diffusion and mesoporosity. The
Monacolin K release has been monitored until 48 hours in simulated intestinal fluid SIF. HMG-CoA reductase activity has been
measured to determine the formulation influence on statin activities against the Lovastatin activity used as control. The selected
formulation enhances the statins release respect to the RYR matrix alone and in addition, the preliminary biological results suggest
that the activity of these samples is associated with the inhibition of HMG-CoA reductase. Release tests pointed out that formulations
obtained combining polymers in a ratio close to 1 (i.e., 40/60 and 50/50) guaranteed a potentiated release of Lovastatin from RYR
inducing also a superior hypocholesterolemizing action both in terms of hepatocytes cholesterol production and inhibitory activity
towards 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA). The most effective one, in hypocholesterolemizing activity,
in terms of inhibitory activity versus HMG-CoA reductase and hepatocytes cholesterol production, was the formulation obtained
combining 40% of K-Carrageenan and 60% of Gellan gum.
Biography
Marco Consumi is a Research Scientist at Department of Biotechnology, Chemistry and Pharmacy in University of Siena, Italy. He has received his PhD in
Biomaterials from University of Trento and studied polymers and polymer based materials for controlled release of active substances in pharmaceutical and
nutraceutical field. As a Postdoctoral Fellow, he was focused on understanding the correlation between the chemical composition of materials and their biological
activity. He has broad expertise in synthesis modification and characterization of polymers (naturals and synthetics) and materials for biomedical applications.
Actually, he is involved in 2 EU ITN projects in bacterial infection topic to fundamentally better understand the biology, chemistry and physical properties of biofilms
and 2 Toscany Region funded projects on nutraceutical filed.