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24th Biotechnology Congress: Research & Innovations
CRISPR Cas9 Technology and Genetic Engineering
Annual Congress on
October 24-25, 2018 | Boston, USA
Journal of Biotechnology & Biomaterials | ISSN: 2155-952X | Volume: 8
RegenerAge system: Therapeutic effects of combinatorial biologics (mRNA and allogenic MSCs)
with a spinal cord stimulation system on a patient with spinal cord section
Joel I Osorio
Westhill University School of Medicine, Mexico
As it has been previously demonstrated that electroporation of Xenopus laevis frog oocytes with normal cells and cancerous
cell lines induces the expression of pluripotency markers and in experimental murine model studies that mRNA extract
(Bioquantine®) purified from intra and extra-oocyte liquid phases of electroporated oocytes) showed potential as a treatment
for a wide range of conditions, including Spinal Cord Injury (SCI) among others. The current study observed beneficial changes
with Bioquantine® administration in a patient with a severe SCI. Pluripotent stem cells have therapeutic and regenerative
potential in clinical situations CNS disorders even cancer. One method of reprogramming somatic cells into pluripotent stem
cells is to expose them to extracts prepared from Xenopus laevis oocytes. The positive human findings for spinal cord injury
with the results from previous animal studies with experimental models of traumatic brain injury and SCI respectively as our
evidence and due to ethical reasons, legal restrictions and a limited number of patients, we were able to treat only a very small
number of patients, deciding to include in our protocol the RestoreSensor SureScan to complete it. Based on the electrical
stimulation for rehabilitation and regeneration after spinal cord injury published by Hamid and MacEwan, we designed an
improved delivery method for the in situ application of MSCs and Bioquantine® in combination with the RestoreSensor®
SureScan®. To the present day the patient who suffered a complete section of spinal cord at T12-L1 shows an improvement
in sensitivity, strength in striated muscle and smooth muscle connection, 13 months after the first treatment and 6 months
after the placement of RestoreSensor® at the level of the lesion, showing an evident improvement on his therapy of physical
rehabilitation (legs movement) on crawling forward and backwards and standing on his feet for the first time and showing a
progressively important functionality on both limbs.
Biography
CEO and Founder of Biotechnology and Regenerative Medicine at RegenerAge International™ (www.regenerage.clinic). Vice President of International Clinical
Development for Bioquark, Inc. ) and Chief Clinical Officer at ReAnima™ Advanced Biosciences (www.reanima.tech). Advance Fellow by the
American Board of Anti-Aging and Regenerative Medicine (A4M), Visiting Scholar at University of North Carolina at Chapel Hill (Dermatology). Fellow in Stem Cell
Medicine by the American Academy of Anti-Aging Medicine and University of South Florida.
Joel I Osorio, J Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C4-097