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Volume 9, Issue 11 (Suppl) J Cancer Sci Ther
ISSN: 1948-5956 JCST, an open access journal Asia Pacific Oncologists 2017
November 20-22, 2017
November 20-22, 2017 Melbourne, Australia
14th Asia Pacific
Oncologists Annual Meeting
Intercellular crosstalk in malignant melanoma
Pavol Szabo1, 2, Lukáš Lacina1, Barbora Dvořánková1 and Karel Smetana1
1Charles University, Czech Republic
2East-Slovak Institute of Cardiovascular Diseases Inc., Slovakia
The incidence of melanoma is increasing globally and curability of advanced disease is still limited. Similarly, to other types
of tumors, the microenvironment is an important factor participating in the control of melanoma biological behavior.
The principal cell populations of melanoma microenvironment include cancer-associated fibroblasts (CAFs), keratinocytes,
tumor-infiltrating leukocytes, endothelia of newly formed vessels and also, the composition of extracellular matrix (ECM)
must be taken into account in this context. The CAFs produce various types of extracellular matrix proteins and a wide panel of
cytokines/chemokines and growth factors such as IL-6, IL-8, and CXCL-1. CAFs isolated from melanoma stimulate aggressive
behavior of tumor cells. Effect of CAF on other types of cells present in melanoma was also well documented. From this point
of view, CAFs as the key factor of melanoma microenvironment represent a potential target for a new type of anti-tumor
therapy.
Biography
Pavol Szabo completed PhD and has lot of experience in studying cancer-stroma interactions. He has focused his research in most abundant cell compartment
of cancer microenvironment cancer associated fibroblasts (CAFs) and use tissues, in vitro, in vivo samples to understand role of CAFs to form reactive cancer
microenvironment.
Pavol Szabo et al., J Cancer Sci Ther 2017, 9:11 (Suppl)
DOI: 10.4172/1948-5956-C1-117