23 / 27
Page 72
Journal of Biotechnology & Biomaterials | ISSN: 2155-952X | Volume: 8
July 23-24, 2018 | Vancouver, Canada
Annual Biotechnology Congress
Transitionmetal complexes/organometallic compounds as anticancer/anti HIVdrugs or in pharmaceutical
industry
Prakash Kinthada
JNTU University, India
C
ancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health.
Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and
alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million
Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a
long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid,
belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and
treating various cancers. Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic
preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime,
Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression
and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and
conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an
isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate
with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium,
Ruthenium, Copper etc.
pk6030882@gmail.comJ Biotechnol Biomater 2018, Volume: 8
DOI: 10.4172/2155-952X-C3-095