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Journal of Biotechnology & Biomaterials | ISSN: 2155-952X | Volume: 8
July 23-24, 2018 | Vancouver, Canada
Annual Biotechnology Congress
Structural elements of a therapeutic vaccine against hepatitis B virus
Abdul Hai
Northern Border University, Saudi Arabia
A
23 kDa molecular weight chimeric protein comprising both the core and surface portions of the Hepatitis B viral envelope has
been designed on the premise that if the HBV surface protein is fused with the core protein of the viral envelope, it can produce
both B-cell and T-cell immune responses. The engineered protein contains 216 amino acids from both the core and surface regions
of the viral envelope protein. NNPREDICT and PSIPRED programs have been used to obtain the secondary structure elements. The
tertiary structure of the protein was predicted using 3D-JIGSAW program. In the predicted structure, α-helices form a helical bundle
domain and the β-strands form another separate domain.
synavia786@gmail.comJ Biotechnol Biomater 2018, Volume: 8
DOI: 10.4172/2155-952X-C3-095