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Volume 9 Journal of Alzheimers Disease & Parkinsonism Alzheimer's Congress 2019
March 20-21, 2019
March 20-21, 2019 Sydney, Australia
11th World Congress on
Alzheimer's Disease & Dementia
Ramel A Carlos et al., J Alzheimers Dis Parkinsonism 2019, Volume 9
DOI: 10.4172/2161-0460-C2-063
Obstructive sleep apnea in various cognitive disorders
Ramel A Carlos1 and Noel Bien T Carlos2
1The Neurology Clinic, USA
2University of Southern California, USA
Introduction: Various research studies suggested an association between Obstructive Sleep Apnea (OSA) and various
cognitive disorders, including Alzheimer’s disease. The degree of OSA has been directly correlated with the severity of cognitive
impairment. Stroke and vascular diseases are significant comorbidities in these patients. We report the occurrence of OSA in
patients with various cognitive disorders on the Island of Guam and correlate the severity of OSA with the results of the
neuropsychological testing and neuroimaging studies.
Method: A retrospective review of medical records of patients evaluated in The Neurology Clinic with the diagnosis of OSA in
patients with various cognitive impairments from July 2016 to July 2018 was conducted.These include patients with Alzheimer's
disease, vascular dementia, unspecified dementia and mild cognitive impairment.
Result: There were 375 patients with various cognitive impairments and 16% have been diagnosed with OSA. Among patients
with OSA, 46% have severe OSA, 38% have moderate OSA and 16% have mild OSA. Severe impairment on Global Cognitive
Scores (GCS) was seen in 60% of patients with severe OSA, 44% of moderate OSA and 20% of mild OSA. Moderate GCS were
seen in 29% of patients with severe OSA, 39% of patients with moderate OSA and 30% of patients with mild OSA. Evidences of
silent stroke were seen in 25% of patients and another 31% have leukoaraiosis on their neuroimaging studies. The occurrences
of vascular diseases including hypertension, diabetes mellitus, hyperlipidemia and cardiac disorders were higher in those with
severe and moderate OSA compared to those with mild OSA and without OSA.
Conclusion: Obstructive sleep apnea is a common comorbidity of patients with various forms of cognitive impairment. The
severity of OSA correlates with the degree of impairment on neuropsychiatric testing. Neuroimaging studies demonstrated
evidences of silent stroke and leukoaraiosis among these patients.
Biography
Ramel A Carlos is currently working as Neurologist at The Neurology Clinic at Guam, USA. He has published numerous research papers and articles in reputed
journals and has various other achievements in the related studies. He has extended his valuable service towards the scientific community with his extensive
research work.