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Volume 9 Journal of Alzheimers Disease & Parkinsonism Alzheimer's Congress 2019
March 20-21, 2019
March 20-21, 2019 Sydney, Australia
11th World Congress on
Alzheimer's Disease & Dementia
White matter hyperintensities and vascular dementia
Yuhong Man, Gang Yao and Jingjing Qi
The Second Hospital of Jilin University, China
Statement of the Problem: Recent studies show that WMHs is a known risk factor for cerebrovascular events such as age,
hypertension and diabetes. The aim of this study was to define the severity of White Matter Hyperintensities (WMHs) and
vascular dementia.
Method: 67 patients (mean age 62.5±4.5 years) with brainMagnetic Resonance Imaging (MRI) confirmedWMHs. The severity
of WMHs was further graded according to the Fazekas scale. WMHs in the deep and subcortical white matter were classified
as follows: Absent (grade 0), only punctate foci (grade 1), early confluent lesions (grade 2) or confluent lesions (grade 3).
Cognitive function was assessed using Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE).
Activity of Daily Life Scale (ADL) was applying for assessment of severity of activity of daily living state. Vascular dementia
met the vascular dementia and differential diagnosis of other type dementia based on widely accepted criteria: Hurtig scale and
NINDS-AIREN criteria with Modified Hachinski Ischemic Scale ≥7 points.
Findings: Among 67 WMHs patients 57 had been found cognitive impairment (85.07%). 41 patients among 57 cognitive
impairment patients were diagnosed with vascular dementia. The cognitive dysfunction decreased gradually and ADL scores
were increased accompanied with the WMHs grades increased, respectively.
Conclusion: WMHs is associated with vascular dementia. The cognitive dysfunction of vascular dementia induced by WMHs
was significantly impaired in abstract thinking ability, visual spatial execution ability, delayed recall ability, orientation,
attention and concentration.
Biography
Yuhong Man has her expertise in headache, cerebral disease and sleep disorders. Her research is in the basics and clinical of the acute and chronic headache,
such as migraine and tension headache. She has 14 years’ of experience in neurology about cerebral disease, sleep disorders, teaching and administration, both
in hospital and education institutions in Jilin University.
Yuhong Man et al., J Alzheimers Dis Parkinsonism 2019, Volume 9
DOI: 10.4172/2161-0460-C2-064