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conferenceseries.com
Volume 9 Journal of Alzheimers Disease & Parkinsonism Alzheimer's Congress 2019
March 20-21, 2019
March 20-21, 2019 Sydney, Australia
11th World Congress on
Alzheimer's Disease & Dementia
Adverse drug events in the elderly in hospital were associated with comprehensive geriatric
assessment score
Akane Oyama, Yasushi Takeya, Tsuneo Nakajima, Miyuki Takeya, Shuko Takada, Yoichi Takami, Ken Sugimoto, Koichi Yamamoto and Hiromi Rakugi
Osaka University, Japan
It has known that the number of medications is associated with increasing risk of Adverse Drug Events (ADEs). In elderly
people, poly pharmacy has also been associated with adverse clinical outcomes, such as disability and cognitive impairment,
falls and fractures, malnutrition, hospitalization, mortality and increasing medical costs. Prescribing drugs to elderly patients
should pay special caution because of age related change in metabolism, excretion, metabolism and distribution. Independent
risk factors for ADEs have been known more than 5 or 6 medication, age, comorbidity and specific drugs (antipsychotics, anti-
infective medication and anticoagulant and antiplatelet drugs etc.). Large majority of ADEs are preventable. The basic goal of
our study was to identify the kinds of patients who more susceptible to ADEs for efficiently reducing ADEs. Our study was a
retrospective study for seeking another risk factors related with ADEs in elderly inpatients from2014 to 2017 in our department.
We suspected that physical and cognitive impairment is also the risk factor of ADEs. Physical frailty was assessed by checking
by hand strength, walking speed, physical activity, exhaustion and weight loss for two or three months and cognitive function
was checked by MMSE. The number of ADEs was 28% in our hospitalized patients. Risk factors of ADE in previous studies
were also risk factor of ADEs in our study. Major risk factor of ADEs identified in our study were comorbidity, duration of
hospitalization and total score of CGA7 but MMSE score and physical frailty not related with AEDs. To reduce preventable
ADEs in elderly inpatients, we may pay more attention to comorbidity and comprehensive geriatric assessment.
Biography
Akane Oyama has specialty in geriatric medicine especially dementia and poly pharmacy. He is a Member of the Japanese Society of Internal Medicine and Japan
Society for Dementia Research.
Akane Oyama et al., J Alzheimers Dis Parkinsonism 2019, Volume 9
DOI: 10.4172/2161-0460-C2-064