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Volume 4, Issue 4(Suppl) J Infect Dis Ther 2016
ISSN: 2332-0877, JIDT an open access journal Infectious Diseases 2016
August 24-26, 2016
Page 50
Notes:
conferenceseries.com
August 24-26, 2016 Philadelphia, USA
&
Infectious DiseasesJoint Event on 2nd World Congress on
Pediatric Care & Pediatric Infectious Diseases
International Conference on
Francis J Castellino, J Infect Dis Ther 2016, 4:4(Suppl)
Conscription of the host fibrinolytic system as a virulence determinant for Streptococcus pyogenes
The virulence determinants of Gram-positive streptococci are more complex than those of Gram-negative strains. For
Gram-negative bacteria, lipopolysaccharide (LPS) is a primary virulence factor. In the case of the human pathogen, Gram-
positive group A-streptococcus pyogenes (GAS) is one virulence factor in the development of a proteolytic surface of GAS cells
and this aid in dissemination of the bacteria from epithelial cells of the skin and throat to deep tissues. For skin-tropic strains,
this is accomplished by hijacking of the host fibrinolytic system by GAS. For this to occur, there must be GAS surface proteins
that bind to the host proenzyme, plasminogen and then the plasminogen must be specifically activated and the proteolytic
is under tight and rapid gene regulation since the proteolytic surface is only required at certain stages of the infection. This
presentation will discuss these features for a virulent skin-tropic strain of GAS.
Biography
Francis J Castellino is the Kleiderer-Pezold Professor of Biochemistry and Director of the WM Keck Center for Transgene Research at the University of Notre Dame,
USA. He has coauthored more that 400 peer reviewed manuscripts.
Francis J Castellino
University of Notre Dame, USA