euro-infectious-diseases-2016_posters-accepted-abstracts

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Volume 4, Issue 5(Suppl) J Infect Dis Ther
ISSN: 2332-0877 JIDT, an open access journal
Page 34
Notes:
Euro Infectious Diseases 2016
September 05-06, 2016
conferenceseries.com
Infectious Diseases
September 05-06, 2016 Frankfurt, Germany
3rd Euro-Global Conference on
Rama Bhat, J Infect Dis Ther 2016, 4:5(Suppl)
Pure red cell aplasia in a patient with human immunodeficiency virus infection
Rama Bhat
Manipal University, India
A52 year old patient with a known case of human immunodeficiency virus infection on zidovudine, lamivudine and nevirapine
since 2 years, presented with severe fatigue. He had severe anemia with hemoglobin of 3.5 gm% with normal leucocyte and
platelet counts. He had no lymphadenopathy or hepatosplenomegaly. His CD4 count was 584 and HIV viral load was undetectable.
Zidovudine was thought to be the cause of anemia and cART was changed to tenofovir, lamivudine and efavirenz. He was given 3
units of packed red cell transfusion and was discharged from the hospital. Patient returned 3 weeks later with severe anemia. A bone
marrow study was done which showed selective suppression of erythrocyte precursors suggestive of pure red cell aplasia. Parvovirus
serology was negative. Lamivudine was substituted with emtricitabine with no response. Antiretroviral therapy was temporarily
discontinued for 4 weeks with no response. Corticosteroid therapy was given but anemia persisted. Finally antiretroviral treatment
was continued with weekly erythropoietin therapy. He has responded with increase in hemoglobin in 4 weeks.
Biography
Rama Bhat has completed his MBBS and MD in Internal Medicine from Mysore University and Goa University in 1988 and 1993 respectively. He is currently working as a
Professor of Medicine at Manipal University, India. He has published 12 articles in national and international journals.