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Therapeutic potential of two different doses of human bone marrow derived mesenchymal stromal cells in treating liver cirrhosis
6th World Congress on Biotechnology
Ashwini Aithal P, K L Bairy and Raviraja N S
Manipal University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
Introduction: Bone marrow derived mesenchymal stromal cells (BM-MSCs) are multipotent adult stem cells that are isolated and characterized from human bone marrow. Aim: To compare the therapeutic potential of two different doses of BM-MSCs (low dose and high dose) in treating CCl4 induced liver cirrhosis in Wistar rats. Materials & Methods: 24 healthy female Wistar rats were used for the study and were randomly divided into four experimental groups: Group A (Control), Group B (CCl4 treated group), Group C (CCl4+low dose of MSCs), Group D (CCl4+high dose of MSCs), each group consisted of 6 animals. On day 0, 6, 12, 18, 24 and 30, blood samples were collected and sera were used for liver enzyme estimation. On the 30th day, animals were sacrificed; liver tissue was used for anti-oxidant analysis and histopathological study. Results: Liver enzyme levels in serum were increased in the CCl4 treated rats. Treatment with MSCs showed significant decrease in liver enzyme levels and decreased oxidative stress when compared to CCl4 treated group (p<0.05). Histopathology examination showed that hepatic architecture of rats treated with MSCs (low dose and high dose) was found to acquire near normalcy when compared to that of CCl4 treated group (Group B). Conclusion: Results indicated that among the two doses of mesenchymal stem cells, high dose of BM-MSCs treatment was more effective in treating liver cirrhosis when compared to low dose of BM-MSCs (p<0.05).Biography
Email: ashwini.anat@gmail.com
