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Statement of the Problem: Alzheimer��?s disease (AD) is a major public health issue in Western societies. Non-pharmacological
therapies are at the forefront of therapeutic strategies du to the current lack of pharmacological treatment. The purpose of
this study was to assess the impact of an educational intervention called Therapeutic Patient Education (TPE) on the AD
patient��?s quality of life, conducted in a dyadic approach (patient/caregiver)
Methodology & Theoretical Orientation:
This randomized, single blind, monocentric controlled trial, called THERAD (Therapeutic Education in Alzheimer��?s Disease)
was conducted in the Toulouse University Hospital in the south of France between 01.01 /2013 and 31.12/2016. THERAD
involved 196 patients and their caregivers (196 dyads), 98 in the intervention group (a structured TPE intervention, with
individual sessions for patients and caregivers and group sessions only for caregivers) and 98 in the control group, both
followed of one year. The primary outcome was the AD patients��? Quality of life (QOL) on the QOL Logsdon scale proxyreported
by caregiver. Secondary outcomes were the AD patients��? QOL self-rated, behavioural and psychological symptoms,
autonomy, caregivers��? burden and QOL.
Findings:
The AD patients��? QOL was not improved when proxy reported by the caregiver but significatively improved when selfreported
by the patient. We did not retrieve any impact of the intervention on others secondary outcomes.
Conclusion & Significance:
Despite possible methodological bias, this result underlines the challenging issue of the QOL assessement, and the importance
of a double perspective in AD. Recent literature report effects of educational intervention when included in a multicomponent
intervention (psychological support, respite care). Moreover, the dyadic approach is now widely used (3). A dyadic approach
in both intervention and assessement seems innovative and inclusive. Among exhausted caregivers, we retrieved a positive
effect of TPE. Thus, the caregiver burden could be the target of future educational interventions. The patient��?s AD patient��?s
QOL remains a mutidimensionnal relevant criterion.
Biography
Dr. Hélène Villars is a French physician, geriatrician, at the Geriatric Department of the Toulouse University Hospital . She earned an MD degree in Geriatrics from Toulouse University and is currently finishing is PhD in Public Health on non pharmacological intervention such as educational intervention adressed to the dyad (patient/caregivers) in Alzheimer’s disease. She is a member of the French Society of Geriatrics In her daily clinical activity at the Toulouse University hospital. Dr. Villars is the head of a day care hospital and a support plateform for nursing home residents during the COVID period
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