ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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The role of bowel bacteria, especially Klebsiella in the causation of Crohn?s disease

3rd International Conference on Gastroenterology & Urology

Alan Ebringer

ScientificTracks Abstracts: J Gastroint Dig Syst

DOI: 10.4172/2161-069X.S1.021

Abstract
Antibodies to Klebsiella bacteria have been measured in 6 different gastro-enterology centres in the U.K.: Birmingham, Glasgow, Edinburgh, Royal Free Hospital-London, University College Hospital-London and King?s College Hospital- London. Elevated levels of antibodies to Klebsiella bacteria were found in all these 6 different centres when compared to local controls. It is suggested that Crohn?s disease is caused by Klebsiella bacteria in HLA-B27 negative individuals. Auto-antibodies to collagens I, III and IV are responsible for the pathological lesions in the gut. A multi-centre study involving anti-Klebsiella therapy should be evaluated in the treatment of Crohn?s disease.
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