Journal of Gastrointestinal & Digestive System
Open Access

Abstract

Background: Ascites due to cirrhosis can be mobilized with sodium restriction (88 mEq/day) and diuretics.Patients with non-responder to diuretics may have pre-hepatorenal syndrome and a poor prognosis.Diuretic response can be monitored by measuring 24-hr UNa which can also be a prognostic marker.The aim of this study was to evaluate the value of 24-hr UNa as a prognostic marker in cirrhotic patient with ascites on diuretics. Methods: This cross-sectional study included 100 patients of cirrhosis on diuretics.24-hour urine was collected properly and tested accordingly.At the same time liver and renal function tests were done to calculate MELD and CTP score. Results: Out of 100, 48 (48%) subjects had excreted ≥78 mmol/d of sodium and 52 (52%) subjects excreted <78mmol/d.64 subjects belong to CTPS “B” and 36 in CTPS “C”group.Majority of the cases (81.3%)of CTPS “B” group had excreted ≥78 mmol sodium/day and 51.9% patients of the CTPS “C” group had 24hr urinary sodium <78 mmol/day.In patients who excreted < 78 mmol/day MELD score was 17.71 ± 4.51 and it was 14.60 ± 2.98 in patients who excreted ≥78mmol/day of urinary sodium. These differences were statistically significant (p<0.001). Conclusion: This study showed that advanced cirrhosis have relatively lower natriuresis in response to diuretics.So, 24-hr UNa can be considered as a prognostic indicator.But multicentered studies are needed for further recommendation.

Biography

E-mail: drsukantadmc@gmail.com