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The potential effect of Epigallocatechin-3-gallate alone or in combination with Vitamin E and selenium on Alzheimers disease induced by aluminum in rats
3rd International Conference on Alzheimers Disease & Dementia
Azza A Ali, Hebatalla I Ahmed and Karema Abu-Elfotuh
Al-Azhar University, Egypt
Posters-Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Background: AlzheimerAAAs disease (AD) is the most common cause of dementia. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea; it is a natural chelator and can reduce iron-accumulation in instance of neurodegenerative diseases. Vitamin E and selenium are antioxidant and have ability to counteract free radicals which contribute to pathological process in AD. Objective: The aim of the study was to evaluate the possible protective effects of EGCG and/or vitamin E and selenium against aluminum-induced AD in rats. Methods: Five groups were used; 1 group served as control and 4 groups were injected daily with ALCL3 70 mg/kg I.P for six week. One of them served as AD model group while the other three groups were treated with EGCG (10 mg/kg, I.P), vitamin E (100 mg/kg, P.O) &selenium (1 mg/kg, P.O) or with their combination daily during AD induction. After 6 weeks all rats were examined in the behavioral tests (Morris water maze and Conditioned avoidance test). Histopathological changes in different brain regions were determined and biochemical parameters (B- amyloid, ACHE, SOD, TAC, and MDA) were also estimated. Results: The results showed significant increase in B- amyloid, ACHE and MDA as well as significant decrease in SOD and TAC in untreated AD model group; in addition to increase in learning time and trials number in the behavioral tests. Hippocampus neuronal degeneration and pyknosis were also detected. EGCG and/or vitamin E &selenium minimized the deteriorating effects of aluminum on biochemical parameters as well as memory and learning impairment, moreover intact hippocampus had been also shown especially in combination treatments; however some plaques were detected in vitamin E &selenium group. Conclusion: EGCG is more effective in minimizing the hazards of Aluminum- induced AD than vitamin E &selenium. However, the combination treatment has more pronounced protective effects than EGCG alone.Biography
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