Journal of Clinical & Experimental Pathology
Open Access

Abstract

Aflatoxicosis is a mycotoxicosis developing acute or chronic conditions caused by aflatoxins in domestic animal and humans. Aflatoxicosis is a widespread problem especially in the underdeveloped and the developing countries. Aflatoxins are potential threat to humans and animal and cause severe economic losses in animal industries. The chronic toxications especially suppress the immune system which facilitates the occurring of many diseases. Liver is main organ affected by aflatoxicosis and are histopathologically observed necrosis, fibrosis and hepatocarcinogenesis. It is not well known the effective protection in aflatoxicosis. However, it is reported that some vitamins, proteins and inorganic substances have a protective effect. In lastly performed studies, it was indicated that Nigella sativa (NS) had many pharmacologic effects as such antioxidant, immunomodulatory and anticancer. However, there is scanty study about their protective effects on aflatoxicosis. This study was planned to investigate the effect of NS on the prevention of aflatoxin-induced liver lesions in rats in term of biochemical, histopathological and immunohistochemical methods. This purpose, a total of 30 rats was allotted into one of three experimental groups: A (Control), B (AFB1-treated) and C (AFB1+NS-treated) each containing 10 animals. The rats were sacrificed at 90th day of the experiment. Blood samples for the biochemical analysis and tissue samples from livers for histopathological examination were taken. On the basis of biochemical and histopathological findings, it is concluded that treated plant extract decrease the lipid peroxidation and liver enzymes, increase the antioxidant defense system activity and prevent the liver damage in the AFB1-treated rats. The study indicates that hepatoprotective effects are obtained from the group C (AFB1+NS -treated).

Biography

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