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Background: Neurodegenerative diseases and disorders present with a wide range of clinical and neuropathological
symptoms caused by progressive neuronal dysfunction and eventual neuronal death. As individuals with neurodegenerative
diseases experience gradual sensory, motor, and cognitive debilitation, the maintenance and recovery of a functional gait
holds physiological, psychological and financial importance. Developments in robotically-aid therapies are becoming more
commonly used as a therapeutic tool for the improvement of gait characteristics and overall motor function for individuals
with various gait impairments. To date, studies examining the effects of robotic-assisted gait training (RAGT) as treatment for
neurodegenerative diseases, have only been performed in individuals with multiple sclerosis (MS), Parkinson�s disease (PD)
and progressive supranuclear palsy (PSP).
Purpose: The purpose of this review is to summarize and show trends to the efficacy of RAGT as a gait restorative and
preservative modality for individuals with these neurodegenerative diseases including MS, PD, and PSP.
Results: The overall trends reported by these reviewed studies show that RAGT may be an effective therapy for producing
significant improvements in multiple gait characteristics including balance, walking speed, endurance, leg strength, gait safety,
and motor function for individuals with neurodegenerative disease.
Conclusion: The studies in this review suggest that RAGT therapies may be an effective substitute for, or addition to, present
conventional therapies for individuals with neurodegenerative disease, however the long-term effects of this therapy is still not
known for these individuals.