Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 3330
Journal of Biotechnology & Biomaterials received 3330 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
The expression of rat serine/threonine protein kinase A-Raf is down-regulated in primary liver cancer
6th World Congress on Biotechnology
Maryam Ranjpour, Saima Wajid and S K Jain
Hamdard University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
Liver cancer is globally associated with very high mortality. Delayed diagnosis and lack of effective treatment are responsible factors affecting its survival rate. In our research for biomarkers that can diagnose HCC, we developed an animal model of chemically induced liver cancer using DEN and AAF as the inducer and promoter of HCC. The progression of disease was monitored by histopathological evaluation. The differentially expressed proteins in sera of treated animals vis-a-vis control animals were analyzed by PDQuest, MALDI-TOF and LCMS. We identified few proteins that have potential for development of biomarkers for early detection of HCC. We report that the expression of serine/threonine protein kinase A-Raf is downregulated at very early stage of cancer development. The down regulation has a co-relation with progression of the disease. Real-time PCR analysis of RNA confirmed it�s down regulation. The effect is at transcription level. Real-time PCR data and Western blot analysis data show that the transcriptomic and proteomic analysis supplement each other. These data suggest that serine/threonine protein kinase A-Raf has strong potential for development of an early diagnostic and prognostic marker for HCC.Biography
Email: maryam_o2001@yahoo.com
