Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

It is well known that medicinal plants play an important role in health care system and can be called as a main source of new chemical substances with potential therapeutic effects. Bioactive compounds in plants can be defined as secondary plant metabolites eliciting pharmacological or toxicological effects in animals. The aim of the present work is to summarize examinations about biologically active substances and pharmacological activity of Teucrium polium. The typical bioactive compounds in plants are produced as secondary metabolites. 24 albino male rats weighting 220�±10 g were divided into four groups each group consists of 6 rat. Group one was considered as the negative control group which received normal saline (5 mL/Kg). 3 groups were injected with the Maximum Tolerated Dose (MTD) of ethanol extract 530 mg/kg intramuscularly (i.m.) (n=6); MTD of ethyl acetate fraction of ethanol extract 385 mg/kg i.m. (n=6); MTD of aqueous fraction of ethanolic extract 400 mg/kg i.m. (n=6). After 24 hours animals were sacrificed, their blood was collected to determine serum enzyme activities of ALT and AST. The results of this study showed the aqueous fraction of ethanol extract of Teucrium polium (without furolactone acids) is not hepatotoxic, which is the basis to conclude that hepatotoxicity is conditioned by furolactone acids.

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