Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

The dysfunction of Na+/K+ pump, which is a common consequence of any pathology, including aging, has a crucial role in regulation of two fundamental cell parameters determining its functional activity such as cell hydration and intracellular Ca2+ homeostasis. However, our weak knowledge on the individual role of different catalytic isoforms of Na+/K+2-ATPase (working molecule of pump) in the regulation of cell hydration and Ca2+ homeostasis in aging as well as their role in regulation of cognitive function of the brain is the main barrier in understanding the nature of primary mechanism responsible for age-related memory loss. This report will present a new data on the study of dose-dependent 3H- ouabain binding with the cell membrane, cell hydration, intracellular messenger systems, Na/Ca and Na/H exchange in brain tissues and cognitive function of rats with different ages. The obtained data allow us to conclude that the age-dependent dysfunction of Na/K-ATPase �±3-isoform dependent intracellular signaling system leading to brain cell dehydration and increase of intracellular Ca2+ contents is responsible for age-induced memory losses. The role of cAMPdependent Ca2+ pump in the membrane of endoplasmic reticulum as well as the role of the cascade calmodulin-Ca-NO productionintracellular cGMP content elevation- Ca2+ efflux activation from the cell in regulation of Ca2+ homeostasis and cognitive function of the brain will be discussed.

Biography

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