Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Targeted Drug Delivery System (TDDS) is the most important research field for the design and development of pharmaceutical drugs. The basic premise of a TDDS is to concentrate the drug in the tissues of interest while reducing the relative concentration of medication in other remaining tissues. As a result, the drug is localized to a greater degree on the targeted site while leaving surrounding tissues unaffected. The ideal drug delivery system delivers drug at rates finely tuned to the biological requirement of the body. Due to their high specificity and efficacy, TDDS are the future in rational drug design and development. The significant advantage with TDDS includes protecting the payload and improving therapeutic index. TDDS has several advantages for the treatment of disease quantitatively. For instance, drug localization, decreased side effects, reduced dosage, modulated pharmacokinetics, controlled biodistribution, and most importantly, improved patient��?s compliance. In this context, TDDS, especially Gold-Based Nanoparticles (AuNPs) will be used as a model system in this work. The main objective and basic principle behind the concept of targeting is that, the specific drug receptor is targeted to fit and improve their binding affinity, to the specific receptor that ultimately will trigger the pharmacological activity.

Biography

Khairia M Youssef is a Professor of Organic Chemistry since 1999. She recieved her Bachelor of Pharmaceutical Sciences degree, Master degree and PhD in Organic Chemistry from Faculty of Pharmacy, Cairo University in 1977, 1980 and 1984, respectively. In 1988, she was on a special research assignment with Etreby Computer in Los Angeles, California, USA. In 1992, she was on a Peace Fellowship for Postdoctoral Research which concerns with “Design and Synthesis of Potential Antileukemic and/or Antiviral 2’-Deoxymethylene Nucleosides” at the University of Southern California, Los Angeles, California, USA, under the supervision of Dr. Eric J Lien, PhD. She published 62 papers in national and international journals. She had been awarded the Bronze award from King Abdul Aziz city for science and technology for the exclusive research “Synthesis of curcumin analogues as potential antioxidant, cancer chemopreventive agents” which had been granted by King Abdul Aziz city for science and technology. She had been awarded a certificate from The Marquis Who’s Who Publications Board as a subject of biographical record in Who’s Who in Science and Engineering (2008-2009), and a silver award from King Abdul Aziz city for science and technology for “Novel Modified Estrogens: Synthesis, Binding Affinity to Estrogen Receptor, Biological and Antitumor Activities of Various Novel Modified Estrogen”. She had been awarded the FUE Azazi Award for Outstanding Research for the academic year 2012-2013. She is an international conference organizer and had been awarded a certificate for participating as organizer for the 1st FUE International Conference on Pharmaceutical Technologies and 3rd FUE International Conference of Pharmaceutical Sciences.

Email: khairiayoussef@yahoo.com