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In Association with
Synergistic formulation for chemoprevention of hepatocellular carcinoma
6th World Congress on Biotechnology
Savita Mishra and Deepshikha Pande Katare
Amity University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
Chemoprevention is a rapidly evolving field in cancer management. It comprises administration of natural, biological or synthetic agents that have the ability to inhibit, reverse, delay or hinder the tumorigenesis process and also prevent transformation of benign cells to malignant cells. Hepatocellular carcinoma (HCC, a third most prevalent cancer) is chronic inflammation related cancer with no potent therapeutic treatments. Natural products such as vitamin and plant derived secondary metabolites (Vitamins, chalcone, polyphenols, alkaloids, terpenes, etc.) has ability to interrupt the biological processes that are involved in carcinogenesis. These compounds can also protect normal cell from the side effect of cytotoxic drugs which are used in the treatment of cancer. Combination of the secondary metabolites compounds with the synthetic drugs can assure lesser side effects with maximum efficacy. Our in vitro studies reports a combinational synergistic formulation to reduce tumorigenic cell growth and restoring the cellular enzyme at normal level. Simultaneously in silco results also suggest that these compounds can be potent ligands for targeting HCC related receptors.Biography
Email: savitasav1986@gmail.com
