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Oropharyngeal cancers are on the rise globally. Of late, many innovations have been applied to optimally treat this complex
cohort of patients. A multidisciplinary treatment approach is crucial in meeting the complex needs of patients with head
and neck disease as well as optimizing oncologic and functional outcomes. In particular, the application of transoral robotic
surgery (TORS), a minimally-invasive, robotic-assisted surgical procedure, to the treatment paradigm has revolutionized the
surgical approach, reducing long-term dysfunction. It offers a faster return to day-to-day activities; significantly less morbidity,
less complications, scarring and risk of infection and reduced risk of long-term swallowing problems. In these cases, adjuvant
radiation is often indicated. For patients with tumors precluding an upfront surgical approach, primary chemoradiation is an
effective treatment. One of the most troubling sequalae from radiation treatment is xerostomia. This is a largely irreversible
change that leads to the development of new medical problems that significantly affect quality of like. Submandibular gland
transfer is a novel approach for preservation of salivary function in the prevention of post-radiation xerostomia. It is a relatively
minor surgical procedure that when performed prior to radiation treatment can significantly improve quality of life. This has
significant implications on patients swallowing function and oral comfort level during and post-treatment. Advances in other
types of treatment techniques are currently in development which may have a major impact on how cancer patients are treated
in the future.