Journal of Biotechnology & Biomaterials
Open Access

Abstract

Plants have been used as bioreactors in recent years to produce industrial enzymes, technical materials and biopharmaceutical. Significant advances in this research field have created new opportunities to decrease the cost of foreign protein production. Generally there are some merits and demerits to produce recombinant proteins in plants. Easy transformation and cultivation make plants suitable for production of many eukaryotic recombinant proteins. However, as negative aspects, expression level of recombinant proteins in plant cell is low and also the extraction and purification of proteins from biochemically complex plant tissues is a laborious and expensive process. In this review article, some strategies such as optimization of transcription and translation, selection of proper targeted organelle in plants and improving the environmental conditions will be discussed. Besides improving the gene expression, downstream processing is one of the most important cost-saving measures to produce recombinant proteins in plants that will be considered to overcome these demerits.

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