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Silkworm gut fibers as novel biomaterials for tissue engineering applications
2nd Annual Conference and Expo on BIOMATERIALS
Ana Pagan, Salvador D Aznar-Cervantes, Luis Meseguer-Olmo, Jose Perez-Rigueiro and Jose L Cenis
Imida Murciano Institute for Agricultural and Food Research and Development, Spain Universidad Cat�³lica de Murcia, Spain Technical University of Madrid, Spain
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
Silk fibroin has been largely studied in tissue engineering due to its excellent physical and biological properties. Based on this, we have developed a new biomaterial consisting of high performance fibers produced directly from the silk glands of silkworms (Bombyxmori) called silkworm gut fibers. This novel biomaterial could be a potential solution in tendon and ligament repair, as these are very common injuries and the traditional surgical reconstruction including auto/allograft and ligament prostheses implants can involve several complications. With this aim, we have braided the silkworm gut fibers, in order to explore the possibility to create a consistent scaffold for ligament repair. The production of the silkworm gut fibers is based on a traditional procedure that consists of immersion of the silk glands in an acidic solution and a subsequent stretching. We evaluated the mechanical properties of 3 silkworm gut fibers weaved in three-strand braids. The biocompatibility assay was also performed by seeding bone marrow adult human mesenchymal stem cells (ahMSCs) on the braided material. 7, 14 and 21 days after seeding, adhesion and proliferation, the cells were studied by SEM and MTT assay, respectively. Our results showed a good and remarkable mechanical strength, with Youngâ��s modulus values of 80�±20 MPa and an ultimate strength of 18�±2 MPa. Moreover, cell adhesion and proliferation were excellent, the cells appeared well spread and attached to the silkworm gut fibers surface, connecting to neighbouring cells and organizing a monolayer over the braided material at day 21 post-seeding. We conclude that silkworm gut fibers combine good mechanical and biological characteristics to be considered a potential biomaterial in tissue engineering applications.Biography
Ana Pagán obtained a degree in Biology from University of Murcia. She has completed her PhD from the same university with a research stay at the Division of Nutrition and Metabolic Diseases, LMU University, Munich, Germany. She works as a Postdoctoral Researcher in the Imida Murciano Institute for Agricultural and Food Research and Development (IMIDA, Murcia, Spain), in the Department of Biotechnology, working on premier biomaterials in tissue engineering.
Email: anapagan@um.es
