Journal of Gastrointestinal & Digestive System
Open Access

Abstract

Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors, while its involvement in renal cell carcinoma (RCC) is not clear and depending on pathological grade. In this case?control study, the association of Cav-1 polymorphisms with RCC risk in a central Taiwanese population was investigated. Ninety two patients with RCC and 6.3-fold amount of age- and gender-matched healthy controls (580) recruited were genotyped. There were significant differences between RCC and control groups in the distributions of their genotypes (P=1.3*10 -3 and 0.323) and allelic frequencies (P=2.8*10 -4 and 1.5*10 -3 ) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a decreased risk of RCC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual RCC susceptibility. This is the first report providing evidence that Cav-1 being involved in RCC, the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky haplotype for the development of RCC and may be novel useful genomic markers for early detection of RCC.

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