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Evidence of the short-term effect of SO2 on hospital admissions for cause-specific Cardiovascular Diseases
(CVD) is still limited. This study aimed to examine the short-term associations between SO2 and causespecific
CVD hospital admission in Beijing. A total of 460,938 hospitalizations for total CVD were obtained
from electronic hospitalization summary reports from 2013 to 2017. A time series analysis was conducted
to investigate the association between SO2 exposure and hospitalizations for total and cause-specific CVD,
including Coronary Heart Disease (CHD), Atrial Fibrillation (AF) and Heart Failure (HF). Stratified analysis
was also conducted by age group (18-64 years and ≥65 years), sex and season. A generalized additive Quasi-
Poisson model was used to examine the associations between SO2 and cause-specific CVD after controlling for
seasonality, day of the week, public holidays and weather conditions. We found an almost linear relationship
between the exposure to SO2 and cause-specific CVD admissions. A 10 μg/m3 increase in the two-day average
concentration (lag0-1) of SO2 was associated with an increase of 1.38% (95% CI: 0.99%; 1.77%) in hospital
admission for total CVD, 1.58% (95% CI: 1.16%; 2%) for CHD and 1.69% (95% CI: 0.41%; 2.99%) for AF.
Nevertheless, a statistically significant association was not observed for admissions for HF. The observed
associations in the single-pollutant models were robust to the inclusion of pollutants in the two-pollutant
model, but the estimate was attenuated when adjusting for fine particulate matter (PM2.5). No difference in the
association was observed for the effect modifiers of sex, season and age. A statistically significant association
between hospitalizations and SO2 was observed. The observed association between SO2 and hospitalization
might not be independent of fine particulate matter (PM2.5) and further studies should be conducted to
demonstrate the independent effect of SO2.
Biography
Endawoke Amsalu has his expertise in environmental epidemiology focused on air pollution. He is currently pursuing his PhD in the Department of Epidemiology and Health Statistics. He focuses on non-communicable disease and also infectious disease.