Epidemiology: Open Access
Open Access

Abstract

T he selective advantage of the ?S?is very controversial in many studies. The objective was to find the existence, to determine the prevalence and the type of severe malaria in different forms of sickle cell anemia. This study is retrospective, descriptive and transversal, for 6 years (2005-2011) in Bonzola Hospital (central DR Congo). The diagnosis of sickle cell anemia was done after electrophoresis of hemoglobin and the diagnosis of severe malaria was done after a positive test and classified according with WHO criteria. 338 children have found to have developed severe malaria during the period of our study, 20 of them were found to have type S hemoglobin which accounts to 5.9% of the whole subjects chosen. 65% of subjects were between 4 and 9 years. The male sex was more predominant than female (sex ratio=1.5).The AA hemoglobin phenotype represent 94.8% of cases (368/388), RR=1.17. 3 forms of severe malaria was found in sickle cell children (AS or SS): anemia in 1.02%, hypoglycemia in 1.55% (RR=1.55), hemoglobinuria in 2.57% (RR=4.5). The parasitemia rate is more important concerning AS children (12/20) than SS children (8/20). Our study showed that severe malaria can occur on sickle cell anemia subjects. Doing further analytical studies would help investigate the biological implications of P. falciparum in sickle cell anemia.

Biography

Oscar Luboya Numbi is a pediatrician since more than 20 years, and a pioneer of public Health in DR Congo. Currently he held the position as the chief of Pediatric Department at University of Lubumbashi. He is also the provincial president of the Congolese Society of Pediatric. He teaches in more than six universities and have publish locally and internationally many papers.