Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

The purpose of this study was to investigate the relationship between serum adipokine levels (adiponectin, leptin) in diabetic and non-diabetic osteoporosis patients. We studied 72 osteoporosis patients (36 diabetic and 36 non-diabetic with body mass index [BMI] 28.1�±5.1 and 27.1�±6.8, respectivety). BMD was studied by dual-energy X-ray absorptiometry from the lumbar spine (L1â��L4) and femoral neck and fasting blood samples were taken for biochemical measurement of fasting blood glucose, Glycosylated hemoglobin, leptin, adiponectin. Fasting levels of plasma adiponectin had a significant positive correlation with BMD of the lumbar spine and a no significant positive correlation with BMD of the femoral neck in the diabetic osteoporosis group (r=0.9, P=0.02/r=0.18, P=0.31, respectively) , but a no significant negative correlation with BMD of the femoral neck and lumbar spine in the non-diabetic osteoporosis group (r=-0.02, P=0.95/r=-0,01, P=0.95, respectively). Leptin did not have a significant correlation with BMD in either the diabetic and non-diabetic osteoporosis groups (P>0.05). The correlation between adiponectin and leptin are not inconclusive.

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