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Regional vulnerability of hippocampal subfields and cognitive decline in Parkinson�s disease
3rd International Conference on Alzheimers Disease & Dementia
Hu Xiaofei, Jiuquan Zhang and Jian Wang
Third Military Medical University, China
Posters-Accepted Abstracts: J Alzheimers Dis Parkinsonism
Abstract
Background and objective: Neuropathological studies show the hippocampus is affected in Parkinson�s disease (PD) withcognitive impairment. In this cross sectional and longitudinal observational study we assess in vivo volumes of different hippocampal subfields in patients with PD with and without cognitive impairment using MRI and test their association with global cognitive decline. Methods: A total of 23 nondemented PD patients, 32 nondemented PD patients with cognitive impairment and 27 neurologically unimpaired elderly controls matched by age and gender were enrolled in this study. 16 PD patients without cognitive decline and 12 PD patientswith cognitive decline were enrolled in follow-up study. We assessed the volumes of seven hippocampal subfields on MRI, including the cornuarmonis (CA) sectors, subiculum, presubiculum, hippocampal tail, hippocampal fissure, fimbria, and the dentategyrus (DG) using a novel technique that enables automated volumetry. Results: In the cross sectional study, the left hippocampal tail subfields were significantly smaller in both groups of PD patients, while the bilateral CA2-3, CA4-DG and subiculum subfields was only reduced in PD patients with cognitive impairment, compared to controls. In the follow-up group, the left fimbria subfields, bilateral CA2-3 and subiculum subfields were significantly smaller in PD patients with cognitive decline compared to without cognitive decline. Significant correlations were found between global cognition and CA2-3, subiculum volumes in follow-up PD patients with cognitive decline. Conclusions: These data show there is cross-sectional and longitudinal regional atrophy of specific hippocampal subfields in PD, which is more severe and further extends to the bilateral CA2-3 and subiculum subfields in patients with cognitive impairment. Our findings indicate that global cognition deficits are associated with volume loss in subfields that act as input regions in the hippocampal circuit, suggesting that degeneration in these regions could be responsible for cognitive dysfunction in PD.Biography
Email: harryzonetmmu@163.com
