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Reduced methylation potential in preterm pregnancies: Implication for epigenetic programming of the offspring
6th World Congress on Biotechnology
Vinita Vivek Khot1, Preeti Chavan-Gautam1, Savita Mehendale2 and Sadhana Joshi1
1Interactive Research School for Health Affairs, India 2Bharati Vidyapeeth University, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Children born preterm are reported to be at increased risk of developing non communicable diseases in later life. Changes in placental DNA methylation patterns are implicated in fetal programming of adult diseases. Our earlier studies in animals have established that micronutrients (folic acid, vitamin B12) and LCPUFA are interlinked in the one carbon cycle influencing methylation reactions. Our studies in women delivering preterm show reduced levels of LCPUFA, altered levels of micronutrients and lowered placental global DNA methylation levels at delivery. We therefore postulate that alterations in the micronutrient metabolism may affect the regulation of the enzymes [methionine adenosyltransferase (MAT2a) and S-adenosyl homocysteine hydrolase (AHCY) in the placenta thereby affecting SAM synthesis and methylation potential in women delivering preterm. The present study examines the mRNA and protein levels of the enzymes [MAT2A and AHCY] along with SAM and SAH levels from preterm (n=73) and term (n=73) placenta. The mRNA levels of enzymes were analyzed by qRT-PCR, protein levels by ELISA and SAM-SAH levels by HPLC. The mRNA levels for MAT2a and AHCY are higher (p<0.05 for both) in the preterm group as compared to term group. SAM and SAH levels were similar in both groups, although SAM: SAH ratio was lower (p<0.05) in the preterm group as compared to term. This data indicates a lower methylation potential in the preterm placenta which may have implications for the epigenetic programming of the developing fetus.Biography
Vinita Vivek Khot has completed her BSc (Life Sciences) in 2009 from RTMNU, MSc (Biotechnology) in 2011 from Bharati Vidyapeeth University and she is currently pursuing PhD in Biotechnology, Department of Nutritional Medicine, Bharati Vidyapeeth University, India under the guidance of Dr. Sadhana Joshi. She has been awarded the Indian Council of Medical Research-Senior Research Fellowship (ICMRSRF) since April 2014 and has 3 papers published in international journals.
Email: vinitak3988@gmail.com
