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The structure guided chemistry department has implemented innovative technologies to design, synthesize and purify target
focused compound libraries with the mission of enabling discovery of novel druglike leads. Compound purification and the
subsequent structure validation are critical steps for successful lead identification and lead optimization campaigns. Supercritical
fluid chromatography-mass spectrometry (SFC-MS) technology has gained wide acceptance for achiral purification in drug
discovery research. The emerging instrumentation, techniques and processes for analytical and preparative SFC-MS will be
discussed. Comparative studies for the application of HPLC and SFC techniques in a high throughput environment will also be presented
Biography
Gerard Rosse has been involved in drug discovery research and development for more than 15 years. He is currently Associate Director, Structure
Guided Chemistry, at Dart Neuroscience and also serves as Adjunct Associate Professor at Drexel University as well as Adjunct Professor in
Medicinal Chemistry at the Pennsylvania Drug Discovery Institute. Prior he functioned in leadership and scientific positions in medicinal chemistry
with Cephalon, Sanofi and F. Hoffman-La Roche. During his industrial tenure, he led multidisciplinary teams and invented multiple pre-clinical
candidates and compound lead series spanning a wide range of therapeutic indications. These include CNS (cognition, schizophrenia, alzheimer?s
disease), inflammation, metabolism, oncology, cardiovascular disease and antibacterial agents. His career is also characterized by implementation
of innovative high throughput technology platforms in the area of small molecules and peptides drug discovery, analytical chemistry and data
management that increased productivity and accelerated the drug discovery process. He is a distinguished speaker at business meetings in US and
Europe and has authored 40+ patents and publications. He received the Ph.D. degree in chemistry from the University of Basel in Switzerland and
postdoctoral training at Stanford University.
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