Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel�® and Alloderm�® of same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks in experimental group of 8 rabbits and they were compared with a control group of 7 untreated animals. Blood flow was measured using the 99mTcO4 clearance technique. Mean blood clearance half time (T1/2) and washout radioactivity was measured. Newly formed vessels were counted by CD31. Mean clearance half time was 4005�±2161.3, 13840�±4644.6 seconds in experimental and control group, respectively in 1��2��1.5 cm (p=0.0125) and 1560�±1174.7, 3405�±807.03 seconds respectively in 2��2��1.5 cm (p=0.0413). Histological examinations revealed that the mean numbers of newly formed vessels in the experimental and control groups were 11�±1.58, 7.8�±1.71, respectively in 1��2��1.5 cm (p=0.0501) and 20.19�±12.47, 12.33�±3.25 respectively in 2��2��1.5 cm (p=0.02679). Lipo-PGE1 was found to be effective at promoting angiogenesis in a rabbit matrix model.

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