Journal of Infectious Diseases & Therapy
Open Access

Abstract

As per 2009 statistics India has the third largest number i.e. 2.3 million PLHIV of which 0.3 million died of tuberculosis.
To improve the quality of life (QOL) it is crucial to identify it’s determinants. Studies have been performed in PLHIV but
there is a dearth of literature on the QOL of HIV-TB co-infected patients.
Aim- To assess and compare the QOL in HIV infected patients with and without TB and identify the factors responsible for
poor QOL.
A cross-sectional study (HIV+ve subjects with and without TB) with non-random sampling was conducted at ART centers.
With 80% power, 95% confidence interval, a ratio of 1:3 of HIV/TB vs HIV without TB and 10% non-responders, sample size
of 104 was calculated. A semi-structured questionnaire collects clinoco-demographical data and Beck’s Depression Inventory
to identify depression by interview, WHOQOL-HIV BREF to assess the QOL by interview and medical record. It had 31 items
divided into six domains:- Physical, Psychological, Social, Level of independence, Environment and Spiritual. For each there
was 5 point likert scale where 1 indicated low/negative perception and 5 high/positive perception. Analysis by SPSS version
11.5 software.
Out of 104 subjects 26(25%) were HIV-TB co-infected (group I) and 78 (75%) only HIV infected (Group II) of which
64(82%) in stage 1 and 14(18%) in stage 2 but all 26 of group I were in stage 3 (p<0.001) and on ART. Only 42(53.8%) of
group I were on ART (p<0.001). The mean (Standard Deviation) of various domains of QOL for group I & II were- Physical
health- 9.92(2.03) & 12.78(2.20) [p<0.001], Psychological health- 10.98(1.78) & 13.18 [p<0.001], Social health – 12.08(2.03)
& 13.24(2.28) [p=0.02], Environmental health- 10.67(1.76) & 13.09(2.17) [p<0.001], Level of independence- 9.73(1.51) &
11.41(2.08) [p<0.001], Spiritual health- 9.77(2.26) & 12.23(2.45) [p<0.001].
HIV infected subjects with TB had poor QOL in all domains and strong association is present between educational status
with QOL. In only HIV positive subjects being on ART and family support was the most important factor.

Biography

Anshu Kumar Jha has completed his MBBS (Bachelor of Medicine and Bachelor of Surgery) at the age of 22 years from Manipal University and is currently pursuing
compulsory rotatory internship (as a part of MBBS) at Kasturba Medical College, Mangalore. As an under-graduate he has done 5 research projects and currently
holds 2 publications in indexed journals. He has also the received the “Youngest speaker award” in the year 2013 at KAPICON (Association of Physicians of India
Conference-Karnata Chapter) 2013 and was selected as the “Indian ambassador” for the ISCOMS (International Student Congress on (bio) Medical Science) 2015
conference.