Journal of Pain & Relief
Open Access

Abstract

Methanolic extracts of Microcos paniculata bark (BME) and fruit (FME) were qualitatively evaluated for phytochemical constituents, as well as to evaluate their anti-inflammatory, analgesic and antipyretic activities. Phytochemical constituents of BME and FME were determined by different qualitative tests such as Molisch�s test, Fehling�s test, alkaloid test, frothing test, FeCl3 test, alkali test, Salkowski�s test and Baljet test. The anti-inflammatory, analgesic and antipyretic activities of the extracts were evaluated through proteinase-inhibitory assay, xylene-induced ear edema test, cotton pellet-induced granuloma formation in mice, formalin test, acetic acid-induced writhing test, tail immersion test and Brewer�s yeast induced pyrexia in mice. M. paniculata extracts revealed the presence of carbohydrates, alkaloids, saponins, tannins, flavonoids and triterpenoids. All of the extracts showed significant (P<0.05, vs. aspirin group) proteinase inhibitory activity, whereas the highest effect elicited by plant extracts was exhibited by the BME (75.94% proteinase inhibition activity). Each extract at the doses of 200 and 400 mg/kg body weight showed significant (P<0.05, vs. control) percentage inhibition of ear edema and granuloma formation. These extracts significantly (P<0.05, vs. control) reduced the paw licking and abdominal writhing of mice. In addition, BME 400 mg/kg, and FME at 200 and 400 mg/kg showed significant (P<0.05, vs. control) analgesic activities at 60 min in the tail immersion test. Again, the significant (P<0.05, vs. control) post-treatment antipyretic activities were found by BME 200 and 400 mg/kg and FME 400 mg/kg, respectively. Study results indicated that M. paniculata could be a source of plant compounds with anti-inflammatory, analgesic and antipyretic activities.

Biography

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