Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 3330
Journal of Biotechnology & Biomaterials received 3330 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Purification of lovastatin from Aspergillus terreus (KM017963) and evaluation of its anticancer and antioxidant activity
6th World Congress on Biotechnology
Bhargavi S D, Praveen V K and Savitha Janakiraman
Bangalore University, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Cervical cancer is the second most common malignancy in women worldwide and thus is one of the leading causes of mortality in women. Lovastatin, a non polar, anti-cholesterol drug has previously been reported to exert antitumor activity in vitro. In the present study, lovastatin from Aspergillus terreus (KM017963) was purified by adsorption chromatography and evaluated for its anticancer and antioxidant properties in human cervical cancer cell lines (HeLa). The growth inhibitory and pro-apoptotic effects of purified lovastatin on HeLa cell lines were investigated by determining its influence on cytotoxicity, Mitochondrial Membrane Potential (MMP), DNA fragmentation and antioxidant property (Hydroxy radical scavenging effect and the levels of total reduced glutathione). Flow cytometry analysis by propidium iodide staining confirmed the induction of apoptotic cell death and revealed cell cycle arrest at G0/G1 phase. Results of the study give leads for anticancer effects of lovastatin and its potential usefulness in the chemotherapy of cervical cancer.Biography
Bhargavi S D has completed her Masters in Microbiology from the Department of Microbiology and Biotechnology, Bangalore University in the year 2011. She is currently pursuing her PhD in the field of Industrial Microbiology in the same department.
Email: drsvtj@yahoo.co.in
