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Introduction: Psychiatric Disorders are in the top leading causes of disease burden and disabilities. Recent
researches are showing huge role of immune dysfunction in the pathophysiology of these disorders. Emerging
future impact for immunological treatment in various psychiatric disorders
Results: In recent years, there has been an increasing recognition of the potential role of immune dysfunction
in the pathophysiology of psychiatric disorders. For example, study findings suggest a connection between
inflammatory immune processes and psychiatric illnesses including mood and psychotic disorders. Some
evidence suggests that the association between psychiatric disorders and stress is mediated, at least in part, by
neuro-inflammatory processes. Several studies identified a positive correlation of serum levels of inflammatory
markers with disease severity and a negative correlation with cognitive performance.
Dysregulation of mainly pro-inflammatory markers, in particular IL-6, IL-2 receptor, IL-1β, IL-17A and
CRP have also been associated with psychiatric disorders. Anti-inflammatory treatment was found to reduce
post-treatment manic symptom scores. Meta-analysis of existing clinical data indicates beneficial effects of
minocycline in patients with depression. Currently, monoclonal antibody treatments are being trialled in
schizophrenia.
In addition, longitudinal research has demonstrated bidirectional links between a personal or family history
of autoimmune disease and increased risk for psychiatric illness.
Conclusion: Over-activation of the immune system is thought to increase brain vulnerability, increasing
the risk of psychiatric symptoms upon a so-called second hit later in life. This hypothesis is supported by a
link between psychiatric diseases, such as schizophrenia, depression and anxiety, and systemic autoimmune
disorders. Current researches hold strong promise for immunological treatment in psychiatric disorders.
Biography
Ammar Alsayegh completed his postgraduate psychiatry training at University of Toronto, Canada. He finished his undergraduate medicine bachelor from University College Cork, Ireland. He is currently the head of Psychiatry Department at Kuwait Center for Mental Health and the Program Director at the postgraduate psychiatry program at Kuwait Institute for Medical Specialization.
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