Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Introduction: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels (up to 1.38 g/100 g) of glutamate. The deficiency of vitamin D is associated with obesity and metabolic syndrome. Objective: The aim of the present study is to determine the effect of co-administration of vitamin D on body weight control in MSGinduced obese rats. Materials & Methods: 18 adult female wistar rats were randomly divided into three groups equally. The first group received a daily oral dose of 5 g/kg body weight of MSG, the second group received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days. The third group was treated with saline served as the control. The body weight, food and water intake was measured. Results: MSG induced rats showed a significant increase (P<0.001) in the body weight, food and water intake but significant decrease (P<0.001) was observed in the rats treated with MSG along with Vitamin D. Conclusion: Ingestion of vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. On a small scale, this also gives an additional benefit of overcoming the largely vitamin D deficient population.

Biography

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