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Protective effect of adenosine A1 agonists against pentylene tetrazole-induced convulsions
3rd International Conference on Clinical Pharmacy
Romany Helmy Thabet, Mohammed Meshal Almutairi, Abdulmajeed Farhan Alenazi, Ahmed Badah Alanazi, Yazen Talal Alenezi and Khalefa Ahmed Alenazi
Northern Border University, Saudi Arabia
ScientificTracks Abstracts: Clin Pharmacol Biopharm
Abstract
Aim of the study: Pentylene tetrazol (PTZ) is a commonly employed chemo-convulsant, used for screening drugs for anticonvulsant activity. The present study is aimed at investigating the differential effects of adenosine and the adenosine A1 agonist, N6- Cyclopentyladenosine (CPA) against seizures induced by pentylenetetrazol (PTZ). Methods: This study was carried out by investigating the effect of pretreatment of rats with adenosine and CPA on pentylene tetrazoleinduced seizures. Acute toxicity of PTZ in rats was studied by determination of median convulsive dose (CD50) of PTZ alone and after pretreatment of rats with each of adenosine and CPA. Results: Adenosine, when administered to rats intra-peritoneally in a dose of 1000 mg/kg 5 minutes prior to acute challenge with PTZ in a dose of 60 mg/kg, produced significant protection against PTZ- induced seizures. CPA, when administered intraperitoneally to rats in a dose of 10 mg/kg 60 minutes prior to acute challenge with PTZ in a dose of 60 mg/kg, also showed significant protection against PTZ induced seizures. Conclusion: CPA significantly protected against seizures after acute PTZ administration and this indicates that the anticonvulsant effect of PTZ is via stimulation of A1 receptors.Biography
Romany Helmy Thabet is a PhD degree holder and an Assistant Professor of Pharmacology, Faculty of Medicine, Northern Borders University, Saudi Arabia. His latest published textbook is “Fundamentals of Medical Pharmacology”. He has several internationally published papers.
Email: Momo19911412@hotmail.com
