Breast Cancer: Current Research
Open Access

Abstract

This study investigated polymorphisms in the promoter regions of IL-6 (-174 G>C) and IL-10 (-1082 G>A) genes through a case-control study. Features like the expression of estrogen and progesterone receptors, involvement of the lymph node, tumor morphology and tumor grades were observed, for the patient group. For the IL-6-174G>C polymorphism, there was significantly higher frequency of C/C genotype in the patients. Further, the C/C genotype was significantly more prevalent among the patients who had lymph node involvement. For the IL-10-1082G>A polymorphism, there was no difference in the distribution of genotypes among the patients and control subjects.

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