Journal of Gastrointestinal & Digestive System
Open Access

Abstract

Yolk sac tumor (YST) of the stomach is extremely rare, with only several cases reported in the English literature. We present a case of primary gastric yolk sac tumor with liver metastases in a 66-year-old male. Preoperative diagnosis was poorly differentiated as adenocarcinoma of stomach. A total gastrectomy was performed. The tumor, with a maximum size of 6.0 cm, was composed microscopically of neoplastic cells with pale eosinophilic cytoplasm. Tumor cells were arranged into solid and papillary structures with several Schiller-Duval bodies. Other components of germ cell tumors, such as embryonal carcinomas and choriocarcinoma, were not identified. The tumor cells were positive for AFP, ﾃ青｡ﾃ青? 18, ﾃ青｡ﾃ青? 20, SALL4, glypican3, but were negative for PLAP, OCT ﾃ?ﾂｾ, ﾃ青｡ﾃ青? 7 by immunohisochemistry. The surgical margins were histologically negative, 12 of 22 resected lymph nodes had metastases. The laboratory findings showed high serum levels of AFP (2502ng/mL); testicles were symmetric with normal size. Primary pure gastric yolk sac tumor is a very rare entity. The rarity of gastric YST makes this diagnosis complicated. However, awareness of this unusual entity and its distinctive immunohistochemical profile invariably leads to a correct diagnosis.

Biography

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