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Present study covered a total of 40 popular and edible tropical marine green-lipped mussel Perna viridis populations which
were collected from 20 geographical sites from the coastal waters of Peninsular Malaysia between 2002-2009. The mussels
were determined for the concentrations of Cd, Cu, Fe, Ni, Pb and Zn in their edible soft tissues. In comparison with the
maximum permissible limits (MPL) set by existing food safety guidelines, all metal concentrations found in all the mussel
populations were lower than the prescribed MPLs. In terms of the heavy metal concentrations determined in the mussels and the
provisional tolerable weekly intake (PTWI) prescribed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
and oral reference doses (RfD)s by the USEPA, all the studied metals (except for Pb) were unlikely to become the limiting
factors for the consumption of mussels from all the populations investigated. The estimated daily intake (EDI) for average level
mussel (ALM) and high level mussel (HLM) consumers of mussels were found to be lower than the RfD guidelines for Cd, Cu,
Fe, Ni and Zn. Furthermore, the target hazard quotient (THQ) were found to be less than 1 for ALM consumers but higher
than 1 for HLM consumers in some sites. Therefore, there were no potential human health risks to the ALM consumers of the
marine mussels. However, for Pb�s THQ values, the Pb levels in some mussel populations could create a health risk problem.
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