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Polyglucosamine In The Treatment Of Overweight And Obesity | 40253
ISSN: 2165-7904
Journal of Obesity & Weight Loss Therapy
Open Access
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Overweight and obesity are one of the major public health challenges of the 21st century and the capacity to face the problem using
non-prescription medicine to support weight loss has been frequently criticized because of scarcity of preclinical data on body
weight reduction and the poor clinical trials available.
Polyglucosamine ( PG L112) is a LMWC (low molecular weight chitosan) that belongs to the category of the medical devices.
It has been tested for the chemico-physical activity showing to be one of the best fat binder available [Froese WM, Ludlow ME.
Food Nutr Sci 2014; 5: 1637-1643]. In particular previous studies documented that the product has very high affinity for oxidized
lipids, which are known to be one of the main causes of gastrointestinal oxidative stress [Cornelli U et al. Phys Reg Med 2006; 1: 25-
29].
Pharmacological studies have clarified its mechanism of action in modifying the microbiota and increasing the glucose
elimination in feces [Bondiolotti G e al. Europ J Pharmac 2007; 567:155-158, Bondiolotti et al. Food Chem 2011;124 :978-982].
Double blind studies in humans comparing PG L112 Vs placebo have shown that the product in combination with a diet is more
effective than the combination of diet +placebo [Cornelli U et al. Minerva Cardioang 2008;56:71-78, Pokhis K et al. BMC Obesity
2015;2: 25].
Similarly, double blind studies in obese subjects comparing the product Vs Orlistat confirmed the significant superiority of PG
L112 in the body weight reduction with an irrelevant incidence of side effects [Stoll M et al BMC Obesity 2015 in press].