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In Association with
Perspectives of breast cancer etiology: Synergistic interactions between smoking carcinogens and exogenous hormone use
3rd International Conference on Epidemiology & Public Health
Hong-Hong Zhu
Posters-Accepted Abstracts: Epidemiology (Sunnyvale)
Abstract
Breast cancer has been a big global health issue since 1990s. Breast cancer incidence ranks first among all women cancers and
continues to rise worldwide, most rapidly in low risk populations. In the past decades, thousands of medical/health/other
scientists have been devoted to breast cancer research. The etiology of breast cancer, however, is not completely understood.
This presentation will address the perspectives of breast cancer etiology and new research directions based on comprehensive
information from molecular medicine, clinical medicine, and epidemiology of breast cancer including (1) plausibility of
smoking in breast carcinogenesis; (2) physiological properties, susceptibility windows, and exposure timing of breast cells; (3)
role of exogenous hormones in breast carcinogenesis; (4) biological mechanisms of synergistic interactions between smoking
and exogenous hormones in breast carcinogenesis; and (5) evidence from epidemiologic studies and the fitted secular trend
between smoking rate, exogenous hormone use, and breast cancer incidence in past decades.
